A fortune 500 medical device manufacturer with operations across America, Europe, and Asia Pacific was struggling with traditional work management frameworks that couldn't keep pace with their fast-changing project environment. The organization faced inefficient prioritization leading to ‘fire brigade’ situations, limited cross-site collaboration despite global project execution requirements, lack of transparency in work allocation and progress tracking, low team autonomy and staff motivation levels, and consequently, unreliable delivery timelines affecting customer satisfaction. Through a vision-driven transformation fostering global delivery of innovative, cost-effective user-centric products through contextual collaboration a culture of continuous improvement was established within an agile, activity-oriented framework. Our tailored SCRUMBAN methodology addressed manufacturing constraints while enabling iterative and incremental delivery. Combined with LEAN principles and implementation of a contextual project management platform, this approach enabled real-time communication, reporting, and analytics that led to significant efficiency and team engagement improvements.